Drug interactions
Brompheniramine + Hydroxyzine
Severity: Moderate
Brompheniramine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating first-generation antihistamines, so combining them increases drowsiness, cognitive impairment and anticholinergic burden. Hydroxyzine also has a QT-prolongation warning, which matters in at-risk patients.
What this interaction means in plain words
Brompheniramine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Avoid duplicate sedating antihistamines and use one agent at the lowest effective dose. Take extra care in older adults and patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Brompheniramine with Hydroxyzine?
MediHelp rates the interaction as moderate. Brompheniramine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating first-generation antihistamines, so combining them increases drowsiness, cognitive impairment and anticholinergic burden. Hydroxyzine also has a QT-prolongation warning, which matters in at-risk patients.
How serious is the interaction between Brompheniramine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate sedating antihistamines and use one agent at the lowest effective dose. Take extra care in older adults and patients with QT risk factors.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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