Drug interactions
Brompheniramine + Iloperidone
Severity: Moderate
Brompheniramine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and iloperidone also causes orthostatic hypotension. Together they may increase drowsiness, dizziness and the risk of falls.
What this interaction means in plain words
Brompheniramine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 and other receptor blockade, with additive antimuscarinic and alpha-adrenergic effects.
What to do
Monitor sedation and orthostatic blood pressure. Prefer a non-sedating antihistamine, and counsel on fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Brompheniramine with Iloperidone?
MediHelp rates the interaction as moderate. Brompheniramine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and iloperidone also causes orthostatic hypotension. Together they may increase drowsiness, dizziness and the risk of falls.
How serious is the interaction between Brompheniramine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure. Prefer a non-sedating antihistamine, and counsel on fall risk.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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