Drug interactions
Brompheniramine + Meperidine
Severity: Moderate
Brompheniramine and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine with anticholinergic effects. With meperidine it can cause additive drowsiness and impaired psychomotor function, and anticholinergic effects such as urinary retention and constipation may be amplified.
What this interaction means in plain words
Brompheniramine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and anticholinergic effects from H1 antagonism and opioid action.
What to do
Avoid driving and alcohol, and use the lowest effective doses. Consider a non-sedating antihistamine, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Meperidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Meperidine?
MediHelp rates the interaction as moderate. Brompheniramine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine with anticholinergic effects. With meperidine it can cause additive drowsiness and impaired psychomotor function, and anticholinergic effects such as urinary retention and constipation may be amplified.
How serious is the interaction between Brompheniramine and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol, and use the lowest effective doses. Consider a non-sedating antihistamine, particularly in older adults.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
