Drug interactions
Brompheniramine + Midazolam
Severity: Moderate
Brompheniramine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a first-generation sedating antihistamine. Combined with midazolam it can increase drowsiness, dizziness and psychomotor impairment.
What this interaction means in plain words
Brompheniramine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression from histamine H1 blockade and GABA-A potentiation.
What to do
Reduce midazolam dose when appropriate and monitor sedation. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Midazolam?
MediHelp rates the interaction as moderate. Brompheniramine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a first-generation sedating antihistamine. Combined with midazolam it can increase drowsiness, dizziness and psychomotor impairment.
How serious is the interaction between Brompheniramine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce midazolam dose when appropriate and monitor sedation. Advise patients to avoid driving and alcohol.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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