Drug interactions
Brompheniramine + Paliperidone
Severity: Moderate
Brompheniramine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine with anticholinergic properties. Together with paliperidone it can increase drowsiness, impair psychomotor performance and add to anticholinergic effects.
What this interaction means in plain words
Brompheniramine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Advise patients to avoid driving or hazardous tasks until response is known. Prefer a non-sedating antihistamine, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Paliperidone?
MediHelp rates the interaction as moderate. Brompheniramine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine with anticholinergic properties. Together with paliperidone it can increase drowsiness, impair psychomotor performance and add to anticholinergic effects.
How serious is the interaction between Brompheniramine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks until response is known. Prefer a non-sedating antihistamine, especially in elderly patients.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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