Drug interactions
Brompheniramine + Papaverine
Severity: Minor
Brompheniramine and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and papaverine may cause drowsiness or dizziness in some patients. Taken together they may modestly increase drowsiness and impair alertness or psychomotor performance.
What this interaction means in plain words
Brompheniramine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brompheniramine belongs to Respiratory; Papaverine belongs to Cardiovascular.
Why it happens
Additive central nervous system depression, with the sedative effect of papaverine being weak and not well characterized.
What to do
Advise patients to avoid driving or operating machinery until they know how the combination affects them, and to avoid alcohol. Reduce the antihistamine dose if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Papaverine?
MediHelp rates the interaction as minor. Brompheniramine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brompheniramine is a sedating first-generation antihistamine, and papaverine may cause drowsiness or dizziness in some patients. Taken together they may modestly increase drowsiness and impair alertness or psychomotor performance.
How serious is the interaction between Brompheniramine and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or operating machinery until they know how the combination affects them, and to avoid alcohol. Reduce the antihistamine dose if excessive drowsiness occurs.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
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