Drug interactions
Brompheniramine + Perphenazine
Severity: Moderate
Brompheniramine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic, so combining them may lead to marked drowsiness, impaired psychomotor performance, dry mouth, urinary retention and confusion. Older patients are especially susceptible.
What this interaction means in plain words
Brompheniramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1 antagonism and phenothiazine activity.
What to do
Counsel against driving and alcohol use, and monitor for anticholinergic toxicity. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Perphenazine?
MediHelp rates the interaction as moderate. Brompheniramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic, so combining them may lead to marked drowsiness, impaired psychomotor performance, dry mouth, urinary retention and confusion. Older patients are especially susceptible.
How serious is the interaction between Brompheniramine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against driving and alcohol use, and monitor for anticholinergic toxicity. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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