Drug interactions
Brompheniramine + Tapentadol
Severity: Moderate
Brompheniramine and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and combined with an opioid can increase drowsiness and impair psychomotor performance. Anticholinergic effects may add to constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression through H1 antagonism and opioid effects.
What to do
Counsel on sedation and avoid driving; consider a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Tapentadol?
MediHelp rates the interaction as moderate. Brompheniramine and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and combined with an opioid can increase drowsiness and impair psychomotor performance. Anticholinergic effects may add to constipation and urinary retention.
How serious is the interaction between Brompheniramine and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving; consider a non-sedating antihistamine if appropriate.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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