Drug interactions
Brompheniramine + Temazepam
Severity: Moderate
Brompheniramine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a sedating antihistamine with a benzodiazepine hypnotic increases drowsiness and impairs coordination and next-day performance. The risk of falls and accidents is higher, particularly in older adults.
What this interaction means in plain words
Brompheniramine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1-receptor blockade and GABA-A potentiation.
What to do
Avoid combining where possible and warn patients against driving or using machinery. Consider a non-sedating antihistamine and the lowest effective temazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Brompheniramine with Temazepam?
MediHelp rates the interaction as moderate. Brompheniramine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a sedating antihistamine with a benzodiazepine hypnotic increases drowsiness and impairs coordination and next-day performance. The risk of falls and accidents is higher, particularly in older adults.
How serious is the interaction between Brompheniramine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and warn patients against driving or using machinery. Consider a non-sedating antihistamine and the lowest effective temazepam dose.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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