Drug interactions
Brompheniramine + Ziconotide
Severity: Moderate
Brompheniramine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide commonly causes dizziness, somnolence and confusion, and a sedating antihistamine may add to these CNS effects. Label guidance advises caution with other CNS depressants.
What this interaction means in plain words
Brompheniramine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziconotide blocks N-type calcium channels while brompheniramine blocks H1 receptors.
What to do
Monitor for increased sedation, confusion and cognitive impairment. Reduce the antihistamine or switch to a non-sedating one if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Ziconotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brompheniramine
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Brompheniramine with Ziconotide?
MediHelp rates the interaction as moderate. Brompheniramine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide commonly causes dizziness, somnolence and confusion, and a sedating antihistamine may add to these CNS effects. Label guidance advises caution with other CNS depressants.
How serious is the interaction between Brompheniramine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, confusion and cognitive impairment. Reduce the antihistamine or switch to a non-sedating one if symptoms occur.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
