Drug interactions
Budesonide-formoterol + Clomipramine
Severity: Major
Budesonide-formoterol and Clomipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine can prolong the QT interval and formoterol may add to this, while tricyclics can intensify the cardiovascular effects of beta-agonists. The result may be tachycardia, palpitations or ventricular arrhythmias.
What this interaction means in plain words
Budesonide-formoterol and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Clomipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and adrenergic stimulation, with tricyclic potentiation of sympathomimetic effects.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor QTc and heart rate, and use alternatives in patients at high cardiac risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Budesonide-formoterol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Clomipramine?
MediHelp rates the interaction as major. Budesonide-formoterol and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clomipramine can prolong the QT interval and formoterol may add to this, while tricyclics can intensify the cardiovascular effects of beta-agonists. The result may be tachycardia, palpitations or ventricular arrhythmias.
How serious is the interaction between Budesonide-formoterol and Clomipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor QTc and heart rate, and use alternatives in patients at high cardiac risk.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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