Drug interactions
Budesonide-formoterol + Dronedarone
Severity: Major
Budesonide-formoterol and Dronedarone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and formoterol may add to this while also lowering potassium and raising heart rate. Combined use increases the risk of serious ventricular arrhythmia. Dronedarone also inhibits CYP3A4 and may modestly increase budesonide exposure.
What this interaction means in plain words
Budesonide-formoterol and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Dronedarone belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and CYP3A4 inhibition by dronedarone.
What to do
Avoid if possible and choose an alternative bronchodilator regimen. If co-administered, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Dronedarone?
MediHelp rates the interaction as major. Budesonide-formoterol and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone prolongs the QT interval and formoterol may add to this while also lowering potassium and raising heart rate. Combined use increases the risk of serious ventricular arrhythmia. Dronedarone also inhibits CYP3A4 and may modestly increase budesonide exposure.
How serious is the interaction between Budesonide-formoterol and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative bronchodilator regimen. If co-administered, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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