Drug interactions
Budesonide-formoterol + Itraconazole
Severity: Moderate
Budesonide-formoterol and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can prolong QT and, through CYP3A4 inhibition, increases exposure to budesonide, raising systemic corticosteroid effects. Formoterol may add to QT effects.
What this interaction means in plain words
Budesonide-formoterol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation and CYP3A4 inhibition raising systemic budesonide levels.
What to do
Monitor ECG and electrolytes in at-risk patients and watch for Cushingoid effects or adrenal suppression with prolonged use. Consider an alternative inhaled steroid such as beclometasone if long-term azole therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Itraconazole?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can prolong QT and, through CYP3A4 inhibition, increases exposure to budesonide, raising systemic corticosteroid effects. Formoterol may add to QT effects.
How serious is the interaction between Budesonide-formoterol and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in at-risk patients and watch for Cushingoid effects or adrenal suppression with prolonged use. Consider an alternative inhaled steroid such as beclometasone if long-term azole therapy is needed.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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