Drug interactions
Budesonide-formoterol + Metoprolol
Severity: Moderate
Budesonide-formoterol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers oppose the bronchodilating effect of formoterol and may precipitate bronchospasm in patients with asthma or COPD. Metoprolol is cardioselective, so the effect is less than with nonselective agents, but it can still reduce formoterol benefit at higher doses.
What this interaction means in plain words
Budesonide-formoterol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Metoprolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, with partial retention of beta-1 selectivity by metoprolol.
What to do
Use the lowest effective dose of metoprolol and monitor respiratory symptoms and lung function. Avoid the combination in poorly controlled asthma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Budesonide-formoterol with Metoprolol?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers oppose the bronchodilating effect of formoterol and may precipitate bronchospasm in patients with asthma or COPD. Metoprolol is cardioselective, so the effect is less than with nonselective agents, but it can still reduce formoterol benefit at higher doses.
How serious is the interaction between Budesonide-formoterol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of metoprolol and monitor respiratory symptoms and lung function. Avoid the combination in poorly controlled asthma.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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