Drug interactions
Budesonide-formoterol + Osilodrostat
Severity: Moderate
Budesonide-formoterol and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both formoterol and osilodrostat can prolong the QT interval. Together they may raise the risk of torsades de pointes, particularly if hypokalemia is present, which formoterol can also cause.
What this interaction means in plain words
Budesonide-formoterol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation, worsened by beta-agonist induced hypokalemia.
What to do
Obtain a baseline ECG and monitor it during therapy. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Osilodrostat
Frequently asked questions
Can I take Budesonide-formoterol with Osilodrostat?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both formoterol and osilodrostat can prolong the QT interval. Together they may raise the risk of torsades de pointes, particularly if hypokalemia is present, which formoterol can also cause.
How serious is the interaction between Budesonide-formoterol and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy. Keep potassium and magnesium within normal range.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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