Drug interactions
Budesonide-formoterol + Osimertinib
Severity: Moderate
Budesonide-formoterol and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and formoterol may also affect repolarisation and lower potassium. Combined use may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Budesonide-formoterol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Osimertinib belongs to Oncology.
Why it happens
Additive QTc prolongation, compounded by beta-agonist induced hypokalemia.
What to do
Monitor ECG and electrolytes periodically, and correct potassium and magnesium abnormalities. Reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Osimertinib
Frequently asked questions
Can I take Budesonide-formoterol with Osimertinib?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and formoterol may also affect repolarisation and lower potassium. Combined use may increase the risk of ventricular arrhythmias.
How serious is the interaction between Budesonide-formoterol and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically, and correct potassium and magnesium abnormalities. Reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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