Drug interactions
Budesonide-formoterol + Perphenazine
Severity: Moderate
Budesonide-formoterol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine may prolong the QT interval and formoterol can add to this effect and reduce potassium. The combination may increase the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Budesonide-formoterol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Consider alternatives in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Budesonide-formoterol with Perphenazine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine may prolong the QT interval and formoterol can add to this effect and reduce potassium. The combination may increase the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Budesonide-formoterol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Consider alternatives in patients with other QT risk factors.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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