Drug interactions
Budesonide-formoterol + Promethazine
Severity: Moderate
Budesonide-formoterol and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine may prolong the QT interval, particularly at high doses or in overdose, and formoterol can add to this effect and lower potassium. The combined risk is modest but relevant in patients with other QT risk factors.
What this interaction means in plain words
Budesonide-formoterol and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Promethazine belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Monitor ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective promethazine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Budesonide-formoterol with Promethazine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine may prolong the QT interval, particularly at high doses or in overdose, and formoterol can add to this effect and lower potassium. The combined risk is modest but relevant in patients with other QT risk factors.
How serious is the interaction between Budesonide-formoterol and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective promethazine dose.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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