Drug interactions
Bumetanide + Deflazacort
Severity: Moderate
Bumetanide and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use raises the risk of hypokalemia with muscle weakness and arrhythmias. Corticosteroid sodium retention may also reduce the diuretic effect.
What this interaction means in plain words
Bumetanide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive kaliuresis from loop diuretic action and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium regularly and supplement potassium as needed. Watch for fluid retention and adjust the diuretic if the response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Bumetanide with Deflazacort?
MediHelp rates the interaction as moderate. Bumetanide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use raises the risk of hypokalemia with muscle weakness and arrhythmias. Corticosteroid sodium retention may also reduce the diuretic effect.
How serious is the interaction between Bumetanide and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and supplement potassium as needed. Watch for fluid retention and adjust the diuretic if the response is reduced.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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