Drug interactions
Bumetanide + Drospirenone
Severity: Moderate
Bumetanide and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, whereas bumetanide increases potassium loss. The net effect varies, and hyperkalemia is possible in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Bumetanide and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Opposing effects on potassium: aldosterone antagonism by drospirenone versus loop diuretic-induced kaliuresis.
What to do
Check serum potassium in the first cycle of combined use and periodically thereafter, particularly with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Drospirenone
Frequently asked questions
Can I take Bumetanide with Drospirenone?
MediHelp rates the interaction as moderate. Bumetanide and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, whereas bumetanide increases potassium loss. The net effect varies, and hyperkalemia is possible in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Bumetanide and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle of combined use and periodically thereafter, particularly with renal impairment.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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