Drug interactions
Bumetanide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Bumetanide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide is a loop diuretic and adds to the diuretic and potassium-wasting effects of the hydrochlorothiazide component. This can cause hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension, especially in elderly patients or those on a low-salt diet.
What this interaction means in plain words
Bumetanide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive natriuresis and urinary potassium loss from sequential blockade of sodium transport in the loop of Henle and the distal tubule, with added volume depletion alongside angiotensin receptor blockade.
What to do
Monitor serum potassium, sodium, magnesium and renal function after starting or changing doses, and watch for orthostatic hypotension. Replace electrolytes as needed and reduce diuretic doses if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bumetanide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide is a loop diuretic and adds to the diuretic and potassium-wasting effects of the hydrochlorothiazide component. This can cause hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension, especially in elderly patients or those on a low-salt diet.
How serious is the interaction between Bumetanide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium, magnesium and renal function after starting or changing doses, and watch for orthostatic hypotension. Replace electrolytes as needed and reduce diuretic doses if volume depletion develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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