Drug interactions
Bumetanide + Flurbiprofen
Severity: Moderate
Bumetanide and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and natriuretic effect of loop diuretics and cause fluid retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Bumetanide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor weight, edema, blood pressure and renal function, and raise the bumetanide dose if response is reduced. Avoid prolonged NSAID use in heart failure or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Flurbiprofen?
MediHelp rates the interaction as moderate. Bumetanide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and natriuretic effect of loop diuretics and cause fluid retention. In volume-depleted patients the combination also raises the risk of acute kidney injury.
How serious is the interaction between Bumetanide and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and raise the bumetanide dose if response is reduced. Avoid prolonged NSAID use in heart failure or dehydration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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