Drug interactions
Bumetanide + Fluticasone-salmeterol
Severity: Moderate
Bumetanide and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salmeterol and loop diuretics can lower serum potassium, so combined use may produce hypokalemia that predisposes to arrhythmias. The effect is mainly relevant at high beta-agonist doses or in acute illness.
What this interaction means in plain words
Bumetanide and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist-driven intracellular potassium shift and diuretic renal potassium loss.
What to do
Monitor serum potassium and magnesium, particularly with high doses or cardiac disease, and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Bumetanide and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salmeterol and loop diuretics can lower serum potassium, so combined use may produce hypokalemia that predisposes to arrhythmias. The effect is mainly relevant at high beta-agonist doses or in acute illness.
How serious is the interaction between Bumetanide and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly with high doses or cardiac disease, and supplement as needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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