Drug interactions
Bumetanide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Bumetanide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop and thiazide diuretics together produce sequential nephron blockade, causing strong diuresis. This can lead to hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive natriuresis and potassium loss from blocking sodium reabsorption at two nephron sites, with added volume depletion alongside ARB therapy.
What to do
Monitor electrolytes, renal function and volume status within the first weeks and after dose changes; replace potassium and magnesium as needed and reduce diuretic doses if volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop and thiazide diuretics together produce sequential nephron blockade, causing strong diuresis. This can lead to hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment.
How serious is the interaction between Bumetanide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function and volume status within the first weeks and after dose changes; replace potassium and magnesium as needed and reduce diuretic doses if volume depleted.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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