Drug interactions
Bumetanide + Hydrochlorothiazide-valsartan
Severity: Moderate
Bumetanide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide and hydrochlorothiazide both cause renal loss of potassium, sodium and magnesium, and together produce potent sequential diuresis. This may cause hypokalemia, hyponatremia, volume depletion and hypotension, and valsartan adds to the risk of renal impairment when volume depleted.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive natriuresis and kaliuresis from loop and thiazide diuretics acting at sequential nephron sites.
What to do
Monitor electrolytes, renal function, weight and blood pressure, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide and hydrochlorothiazide both cause renal loss of potassium, sodium and magnesium, and together produce potent sequential diuresis. This may cause hypokalemia, hyponatremia, volume depletion and hypotension, and valsartan adds to the risk of renal impairment when volume depleted.
How serious is the interaction between Bumetanide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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