Drug interactions
Bumetanide + Ibuprofen
Severity: Moderate
Bumetanide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the diuretic and natriuretic effect of bumetanide and cause fluid retention. In patients with heart failure, cirrhosis or kidney disease, the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Bumetanide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor weight, edema, blood pressure and renal function, and increase the diuretic dose if response is blunted. Use the lowest effective ibuprofen dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Ibuprofen?
MediHelp rates the interaction as moderate. Bumetanide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the diuretic and natriuretic effect of bumetanide and cause fluid retention. In patients with heart failure, cirrhosis or kidney disease, the combination also raises the risk of acute kidney injury.
How serious is the interaction between Bumetanide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and increase the diuretic dose if response is blunted. Use the lowest effective ibuprofen dose for the shortest time.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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