Drug interactions
Bumetanide + Lofexidine
Severity: Moderate
Bumetanide and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and bumetanide adds blood pressure reduction through potent diuresis. Together they can cause symptomatic hypotension and syncope. Bumetanide-induced hypokalemia or hypomagnesemia may also add to lofexidine's QT risk.
What this interaction means in plain words
Bumetanide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of central alpha-2 agonism and loop diuretic volume depletion, with electrolyte loss adding to QT risk.
What to do
Monitor blood pressure, pulse and electrolytes. Reduce the dose of either drug if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Bumetanide with Lofexidine?
MediHelp rates the interaction as moderate. Bumetanide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and bumetanide adds blood pressure reduction through potent diuresis. Together they can cause symptomatic hypotension and syncope. Bumetanide-induced hypokalemia or hypomagnesemia may also add to lofexidine's QT risk.
How serious is the interaction between Bumetanide and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, pulse and electrolytes. Reduce the dose of either drug if symptomatic hypotension or bradycardia develops.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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