Drug interactions
Bumetanide + Metformin-repaglinide
Severity: Moderate
Bumetanide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can raise blood glucose and may impair glycemic control. Volume depletion and reduced renal function from bumetanide can also raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Bumetanide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism by diuretic-induced hyperglycemia, plus possible reduced renal clearance of metformin through volume depletion.
What to do
Monitor blood glucose and renal function, and keep the patient hydrated. Reduce or stop metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Bumetanide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can raise blood glucose and may impair glycemic control. Volume depletion and reduced renal function from bumetanide can also raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Bumetanide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and keep the patient hydrated. Reduce or stop metformin if renal function declines.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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