Drug interactions
Bumetanide + Naproxen
Severity: Moderate
Bumetanide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can reduce the diuretic and natriuretic response to bumetanide and may cause fluid retention. In vulnerable patients the combination can also contribute to acute kidney injury.
What this interaction means in plain words
Bumetanide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and loop diuretic natriuresis.
What to do
Monitor weight, edema, blood pressure and renal function, and increase the diuretic dose if response is diminished. Avoid NSAIDs in heart failure or volume depletion where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Naproxen?
MediHelp rates the interaction as moderate. Bumetanide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can reduce the diuretic and natriuretic response to bumetanide and may cause fluid retention. In vulnerable patients the combination can also contribute to acute kidney injury.
How serious is the interaction between Bumetanide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and increase the diuretic dose if response is diminished. Avoid NSAIDs in heart failure or volume depletion where possible.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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