Drug interactions
Bumetanide + Paroxetine
Severity: Moderate
Bumetanide and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum sodium, so combined use may increase hyponatremia risk, especially in older adults. Severe hyponatremia may cause confusion, falls or seizures.
What this interaction means in plain words
Bumetanide and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Paroxetine belongs to Central Nervous System.
Why it happens
Diuretic-induced sodium loss combined with SSRI-associated SIADH-like water retention.
What to do
Measure serum sodium at baseline and shortly after starting or changing doses, and reassess therapy if it falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Bumetanide with Paroxetine?
MediHelp rates the interaction as moderate. Bumetanide and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum sodium, so combined use may increase hyponatremia risk, especially in older adults. Severe hyponatremia may cause confusion, falls or seizures.
How serious is the interaction between Bumetanide and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum sodium at baseline and shortly after starting or changing doses, and reassess therapy if it falls.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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