Drug interactions
Bumetanide + Streptomycin
Severity: Major
Bumetanide and Streptomycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics given with aminoglycosides increase the risk of hearing and vestibular damage, which may be permanent. Diuretic-induced volume depletion can also raise aminoglycoside nephrotoxicity.
What this interaction means in plain words
Bumetanide and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive cochlear and renal toxicity, with loop diuretic effects on the inner ear and volume depletion increasing aminoglycoside exposure.
What to do
Avoid the combination when possible, or use the lowest effective doses and keep the patient well hydrated. Monitor renal function, aminoglycoside levels and hearing or balance symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Streptomycin
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Streptomycin?
MediHelp rates the interaction as major. Bumetanide and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics given with aminoglycosides increase the risk of hearing and vestibular damage, which may be permanent. Diuretic-induced volume depletion can also raise aminoglycoside nephrotoxicity.
How serious is the interaction between Bumetanide and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, or use the lowest effective doses and keep the patient well hydrated. Monitor renal function, aminoglycoside levels and hearing or balance symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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