Drug interactions
Bumetanide + Tadalafil
Severity: Minor
Bumetanide and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil's vasodilating effect may add to the blood pressure reduction and volume loss from bumetanide, leading to hypotension or dizziness. This is more likely in volume-depleted patients.
What this interaction means in plain words
Bumetanide and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bumetanide belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic blood pressure lowering from PDE5 inhibition and diuresis.
What to do
Monitor blood pressure and hydration status, and counsel patients to report lightheadedness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Tadalafil?
MediHelp rates the interaction as minor. Bumetanide and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil's vasodilating effect may add to the blood pressure reduction and volume loss from bumetanide, leading to hypotension or dizziness. This is more likely in volume-depleted patients.
How serious is the interaction between Bumetanide and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and hydration status, and counsel patients to report lightheadedness.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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