Drug interactions
Bumetanide + Triamterene
Severity: Moderate
Bumetanide and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide increases potassium excretion while triamterene reduces it, so the combination may balance potassium but can also produce either hyper- or hypokalemia. Risk of hyperkalemia is higher with renal impairment, diabetes or other potassium-raising drugs.
What this interaction means in plain words
Bumetanide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Opposing renal potassium effects: loop diuretic kaliuresis versus ENaC blockade by triamterene, with additive diuresis.
What to do
Monitor serum potassium and renal function regularly, and avoid potassium supplements unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Bumetanide with Triamterene?
MediHelp rates the interaction as moderate. Bumetanide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide increases potassium excretion while triamterene reduces it, so the combination may balance potassium but can also produce either hyper- or hypokalemia. Risk of hyperkalemia is higher with renal impairment, diabetes or other potassium-raising drugs.
How serious is the interaction between Bumetanide and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly, and avoid potassium supplements unless hypokalemia is documented.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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