Drug interactions
Buprenorphine + Metoclopramide
Severity: Moderate
Buprenorphine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can slow gastric emptying and intestinal motility, opposing metoclopramide's effect. Both drugs also contribute to sedation and CNS depression.
What this interaction means in plain words
Buprenorphine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Opioid-induced reduction in gastrointestinal motility and additive CNS depression.
What to do
Monitor for sedation and reduced antiemetic or prokinetic effect. Use the lowest effective doses and adjust the regimen if the response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Metoclopramide?
MediHelp rates the interaction as moderate. Buprenorphine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can slow gastric emptying and intestinal motility, opposing metoclopramide's effect. Both drugs also contribute to sedation and CNS depression.
How serious is the interaction between Buprenorphine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduced antiemetic or prokinetic effect. Use the lowest effective doses and adjust the regimen if the response is poor.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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