Drug interactions
Buprenorphine buccal + Enzalutamide
Severity: Moderate
Buprenorphine buccal and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can speed up the breakdown of buprenorphine. Lower buprenorphine exposure may lead to reduced pain control or opioid withdrawal symptoms.
What this interaction means in plain words
Buprenorphine buccal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by enzalutamide increases the metabolic clearance of buprenorphine.
What to do
Monitor for loss of analgesia or withdrawal symptoms and titrate the buprenorphine dose as needed. If enzalutamide is stopped, reassess for opioid excess and sedation as induction wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Enzalutamide?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can speed up the breakdown of buprenorphine. Lower buprenorphine exposure may lead to reduced pain control or opioid withdrawal symptoms.
How serious is the interaction between Buprenorphine buccal and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of analgesia or withdrawal symptoms and titrate the buprenorphine dose as needed. If enzalutamide is stopped, reassess for opioid excess and sedation as induction wanes.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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