Drug interactions
Buprenorphine buccal + Lisdexamfetamine
Severity: Moderate
Buprenorphine buccal and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is a stimulant and buprenorphine is an opioid that causes sedation and respiratory depression. The stimulant may mask sedation without reducing the opioid's respiratory effects, and both drugs have misuse potential. Patients may also have an increased risk of serotonergic toxicity.
What this interaction means in plain words
Buprenorphine buccal and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects, with possible additive serotonergic activity; the net effect is unpredictable.
What to do
Monitor for excessive sedation, respiratory depression and signs of serotonin toxicity, especially at initiation and dose changes. Use the lowest effective doses and reassess the need for both drugs regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is a stimulant and buprenorphine is an opioid that causes sedation and respiratory depression. The stimulant may mask sedation without reducing the opioid's respiratory effects, and both drugs have misuse potential. Patients may also have an increased risk of serotonergic toxicity.
How serious is the interaction between Buprenorphine buccal and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, respiratory depression and signs of serotonin toxicity, especially at initiation and dose changes. Use the lowest effective doses and reassess the need for both drugs regularly.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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