Drug interactions
Buprenorphine buccal + Metoclopramide
Severity: Moderate
Buprenorphine buccal and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can depress the central nervous system, so taking them together may cause more sedation, dizziness and psychomotor impairment than either alone. Opioids also slow gastric emptying and oppose the prokinetic action of metoclopramide.
What this interaction means in plain words
Buprenorphine buccal and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, with opioid-mediated reduction of gastrointestinal motility antagonizing metoclopramide.
What to do
Monitor for excess sedation and reduced antiemetic or prokinetic benefit, and reduce the dose of either agent if drowsiness develops. Counsel the patient to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Buprenorphine buccal with Metoclopramide?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can depress the central nervous system, so taking them together may cause more sedation, dizziness and psychomotor impairment than either alone. Opioids also slow gastric emptying and oppose the prokinetic action of metoclopramide.
How serious is the interaction between Buprenorphine buccal and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduced antiemetic or prokinetic benefit, and reduce the dose of either agent if drowsiness develops. Counsel the patient to avoid driving until the response is known.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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