Drug interactions
Buprenorphine long-acting + Chlorpromazine
Severity: Major
Buprenorphine long-acting and Chlorpromazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine and long-acting injectable buprenorphine both cause CNS depression and may prolong the QT interval. Because the injection cannot be withdrawn quickly, adverse effects may be prolonged.
What this interaction means in plain words
Buprenorphine long-acting and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression with additive QT prolongation.
What to do
Use together only when alternatives are inadequate, and monitor for sedation, respiratory depression and ECG changes. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Chlorpromazine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine and long-acting injectable buprenorphine both cause CNS depression and may prolong the QT interval. Because the injection cannot be withdrawn quickly, adverse effects may be prolonged.
How serious is the interaction between Buprenorphine long-acting and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and monitor for sedation, respiratory depression and ECG changes. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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