Drug interactions
Buprenorphine long-acting + Leuprolide
Severity: Minor
Buprenorphine long-acting and Leuprolide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide may prolong the QT interval, and buprenorphine has modest QT effects. The long-acting injection gives steady exposure, so the added risk is generally small but matters in patients with other risk factors.
What this interaction means in plain words
Buprenorphine long-acting and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes in patients with additional QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Buprenorphine long-acting with Leuprolide?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leuprolide may prolong the QT interval, and buprenorphine has modest QT effects. The long-acting injection gives steady exposure, so the added risk is generally small but matters in patients with other risk factors.
How serious is the interaction between Buprenorphine long-acting and Leuprolide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with additional QT risk factors.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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