Drug interactions
Buprenorphine long-acting + Lisdexamfetamine
Severity: Moderate
Buprenorphine long-acting and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines and opioids such as buprenorphine can both raise serotonergic activity, and serotonin syndrome has been reported with such combinations. Presentation includes agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity. A long-acting injection cannot be withdrawn quickly, so effects may persist.
What this interaction means in plain words
Buprenorphine long-acting and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects: amphetamines increase serotonin release and buprenorphine has weak serotonergic activity.
What to do
Monitor closely for serotonin syndrome, especially when starting lisdexamfetamine or changing its dose. If it is suspected, stop the serotonergic agents and give supportive care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines and opioids such as buprenorphine can both raise serotonergic activity, and serotonin syndrome has been reported with such combinations. Presentation includes agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity. A long-acting injection cannot be withdrawn quickly, so effects may persist.
How serious is the interaction between Buprenorphine long-acting and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for serotonin syndrome, especially when starting lisdexamfetamine or changing its dose. If it is suspected, stop the serotonergic agents and give supportive care.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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