Drug interactions
Buprenorphine long-acting + Metoclopramide
Severity: Moderate
Buprenorphine long-acting and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can depress the central nervous system, so taking them together may cause more sedation and impaired alertness. Opioids also slow gastric transit and oppose the prokinetic effect of metoclopramide.
What this interaction means in plain words
Buprenorphine long-acting and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, with opioid-mediated reduction of gastrointestinal motility antagonizing metoclopramide.
What to do
Monitor for sedation and for loss of prokinetic effect, and lower the metoclopramide dose if drowsiness occurs. Counsel the patient about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Buprenorphine long-acting with Metoclopramide?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can depress the central nervous system, so taking them together may cause more sedation and impaired alertness. Opioids also slow gastric transit and oppose the prokinetic effect of metoclopramide.
How serious is the interaction between Buprenorphine long-acting and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of prokinetic effect, and lower the metoclopramide dose if drowsiness occurs. Counsel the patient about driving and operating machinery.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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