Drug interactions
Buprenorphine subdermal implant + Enzalutamide
Severity: Major
Buprenorphine subdermal implant and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide can lower buprenorphine plasma concentrations and cause withdrawal or loss of effect, and the implant cannot be dose-adjusted. Stopping the inducer later may raise levels and cause opioid toxicity.
What this interaction means in plain words
Buprenorphine subdermal implant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 induction by enzalutamide increases buprenorphine clearance.
What to do
Monitor for withdrawal and consider removing the implant and switching to an adjustable buprenorphine form if enzalutamide must continue.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Enzalutamide?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide can lower buprenorphine plasma concentrations and cause withdrawal or loss of effect, and the implant cannot be dose-adjusted. Stopping the inducer later may raise levels and cause opioid toxicity.
How serious is the interaction between Buprenorphine subdermal implant and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal and consider removing the implant and switching to an adjustable buprenorphine form if enzalutamide must continue.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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