Drug interactions
Buprenorphine subdermal implant + Leuprolide
Severity: Minor
Buprenorphine subdermal implant and Leuprolide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide may prolong the QT interval, while buprenorphine has some QT-prolonging effect. The implant gives steady low exposure, so the added risk is likely small but relevant in high-risk patients.
What this interaction means in plain words
Buprenorphine subdermal implant and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG if the patient has other QT risk factors, and correct electrolyte abnormalities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Leuprolide?
MediHelp rates the interaction as minor. Buprenorphine subdermal implant and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leuprolide may prolong the QT interval, while buprenorphine has some QT-prolonging effect. The implant gives steady low exposure, so the added risk is likely small but relevant in high-risk patients.
How serious is the interaction between Buprenorphine subdermal implant and Leuprolide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG if the patient has other QT risk factors, and correct electrolyte abnormalities.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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