Drug interactions
Buprenorphine subdermal implant + Propofol
Severity: Major
Buprenorphine subdermal implant and Propofol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine is a partial opioid agonist that adds to the sedation and respiratory depression of propofol. The implant gives continuous exposure that cannot be quickly withdrawn.
What this interaction means in plain words
Buprenorphine subdermal implant and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor activity and propofol's GABAergic action.
What to do
Do not stop buprenorphine solely for anesthesia without specialist input; instead, reduce propofol doses and titrate to effect. Monitor ventilation and oxygenation continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Propofol
Frequently asked questions
Can I take Buprenorphine subdermal implant with Propofol?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine is a partial opioid agonist that adds to the sedation and respiratory depression of propofol. The implant gives continuous exposure that cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine subdermal implant and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop buprenorphine solely for anesthesia without specialist input; instead, reduce propofol doses and titrate to effect. Monitor ventilation and oxygenation continuously.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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