Drug interactions
Buprenorphine transdermal + Enzalutamide
Severity: Moderate
Buprenorphine transdermal and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide strongly induces CYP3A4, which may lower circulating buprenorphine delivered by the patch. Reduced analgesic effect or withdrawal symptoms may result.
What this interaction means in plain words
Buprenorphine transdermal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolism of buprenorphine.
What to do
Monitor pain control and withdrawal signs and adjust the patch strength or add supplemental analgesia if needed. Reassess the dose if enzalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Enzalutamide?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide strongly induces CYP3A4, which may lower circulating buprenorphine delivered by the patch. Reduced analgesic effect or withdrawal symptoms may result.
How serious is the interaction between Buprenorphine transdermal and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal signs and adjust the patch strength or add supplemental analgesia if needed. Reassess the dose if enzalutamide is discontinued.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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