Drug interactions
Bupropion + Clopidogrel
Severity: Moderate
Bupropion and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel and its metabolites inhibit CYP2B6, which can raise bupropion and reduce formation of hydroxybupropion. Higher bupropion exposure may cause tremor, insomnia, or seizures.
What this interaction means in plain words
Bupropion and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Clopidogrel belongs to Cardiovascular.
Why it happens
Inhibition of CYP2B6-mediated bupropion hydroxylation by clopidogrel.
What to do
Monitor for bupropion adverse effects, and consider a lower bupropion dose when co-administered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Clopidogrel
Frequently asked questions
Can I take Bupropion with Clopidogrel?
MediHelp rates the interaction as moderate. Bupropion and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel and its metabolites inhibit CYP2B6, which can raise bupropion and reduce formation of hydroxybupropion. Higher bupropion exposure may cause tremor, insomnia, or seizures.
How serious is the interaction between Bupropion and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bupropion adverse effects, and consider a lower bupropion dose when co-administered.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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