Drug interactions
Bupropion + Dapagliflozin-metformin
Severity: Moderate
Bupropion and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion and its metabolites may inhibit renal cation transporters and increase metformin exposure. Higher metformin levels can raise the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Bupropion and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin.
What to do
Monitor glycemic response, renal function and signs of metformin toxicity, and reduce the metformin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Bupropion and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion and its metabolites may inhibit renal cation transporters and increase metformin exposure. Higher metformin levels can raise the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Bupropion and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response, renal function and signs of metformin toxicity, and reduce the metformin dose if adverse effects occur.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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