Drug interactions
Bupropion + Deutetrabenazine
Severity: Major
Bupropion and Deutetrabenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This increases the risk of sedation, akathisia, parkinsonism, depression and QT prolongation.
What this interaction means in plain words
Bupropion and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Bupropion inhibits CYP2D6, reducing clearance of deutetrabenazine's active dihydro-metabolites.
What to do
Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while bupropion is used. Monitor for adverse effects such as depression, somnolence and QT prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Bupropion with Deutetrabenazine?
MediHelp rates the interaction as major. Bupropion and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This increases the risk of sedation, akathisia, parkinsonism, depression and QT prolongation.
How serious is the interaction between Bupropion and Deutetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while bupropion is used. Monitor for adverse effects such as depression, somnolence and QT prolongation.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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