Drug interactions
Bupropion + Dutasteride-tamsulosin
Severity: Moderate
Bupropion and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and can substantially increase tamsulosin exposure. This may cause dizziness, orthostatic hypotension and syncope, especially in older patients.
What this interaction means in plain words
Bupropion and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Bupropion and its metabolites inhibit CYP2D6, reducing tamsulosin metabolism.
What to do
Monitor for orthostatic hypotension, particularly after starting or increasing bupropion. Use the lowest effective tamsulosin dose and counsel on slow position changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Bupropion and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion is a strong CYP2D6 inhibitor and can substantially increase tamsulosin exposure. This may cause dizziness, orthostatic hypotension and syncope, especially in older patients.
How serious is the interaction between Bupropion and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension, particularly after starting or increasing bupropion. Use the lowest effective tamsulosin dose and counsel on slow position changes.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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