Drug interactions
Bupropion + Isavuconazonium
Severity: Moderate
Bupropion and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole lowers bupropion exposure, which may reduce its antidepressant or smoking-cessation efficacy. The effect is modest but can be clinically relevant.
What this interaction means in plain words
Bupropion and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole induces CYP2B6, increasing the metabolism of bupropion.
What to do
Monitor clinical response and increase the bupropion dose if needed, without exceeding the maximum recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Isavuconazonium?
MediHelp rates the interaction as moderate. Bupropion and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole lowers bupropion exposure, which may reduce its antidepressant or smoking-cessation efficacy. The effect is modest but can be clinically relevant.
How serious is the interaction between Bupropion and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the bupropion dose if needed, without exceeding the maximum recommended dose.
What other medicines interact with Isavuconazonium?
MediHelp also lists interactions of Isavuconazonium with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Isavuconazonium page.
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